В сосудистой хирургии нередко выполняют пересадку кровеносных сосудов. В частности, это относится к коронарному шунтированию. Обычно врачи берут фрагмент сосуда из другой части тела пациента, чаще всего это ноги. Это возможно далеко не во всех случаях, а трансплантация сосуда от донора или животного недостаточно безопасна и эффективна. При должном обеспечении сосуд изготавливают искусственно, выращивая в лаборатории культуру из клеток, забранных у пациента, и затем сворачивая их в трубочку. Это не только дорого, но и очень долго: процедура может занять до 9 месяцев, а приготовить такие сосуды заранее и хранить до момента операции просто невозможно.
Шеннон Даль (Shannon Dahl) со своей командой нашли решение этой проблемы. Их метод состоит во взятии клеток гладкой мышечной ткани у донора (или трупа) и выращивании их уже на свернутой в трубку подложке, составленной из биоразложимого полимера – полигликолевой кислоты. Растя и размножаясь на этой подложке, клетки сами вырабатывают коллаген и другие элементы внеклеточного матрикса, скрепляющие и объединяющие их в целостную структуру даже тогда, когда подложка окончательно разложится. Затем клетки удаляют специальным раствором – и получают чистый биогенный полимерный матрикс, подходящий для трансплантации, не вызывающий иммунных реакций и способный храниться чуть ли не целый год.
Были проведены испытания на бабуинах. Восьмерым подопытным животным такие сосуды пересаживали в руку, после чего наблюдали за реакцией. Все прошло отлично: отторжения имплантата не возникло, в течение полугода сосуд оставался полностью функциональным и не забивался сгустками крови. Несмотря на то, что состоял из человеческого коллагена и полимеров внеклеточного матрикса.
По словам изобретателей, метод позволит создавать 37 больших и 74 маленьких кровеносных сосудов на один донорский! И когда возникнет нужда в трансплантации, хирург просто откроет холодильник и выберет нужный.
Следующий этап испытаний будет проходить уже на людях, и если все пройдет успешно, то это будет прорыв в лечении ишемической болезни сердца. И можно будет не ограничивать себя в приеме жирной пищи, ведь теперь всегда можно будет заменить свои сосуды. *Написал radiolog, нарезая, тонкими ломтиками сало.
Статья на английском/русскомизображение сосуда.

Запись опубликована в рубрике Просто интересно. Добавьте в закладки постоянную ссылку.

104 отзыва на “Сосуды

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